Glia is an NMODL asset manager. It can be used with Arbor and NEURON to automatically compile, build, and import assets at runtime. The asset manager caches compiled results and automatically recompiles it when the source code or environment changes. Packaging your mod files as a Glia package allows you to distribute them as dependencies of your Python models and delegates the installation, distribution, versioning and archiving of your assets to your favorite Python package manager. Usage ===== Glia can be installed from pip:: pip install nmodl-glia Glia will check whether packages have been added, changed or removed and will recompile and load the library if necessary. This means that except for importing Glia there's not much you need to do! .. code-block:: python from neuron import h import glia as g section = h.Section(name="soma") # Load your favourite Kv1 mechanism. g.insert(section, "Kv1") # Note: to load the library at import time you can import glia.library instead import glia.library Glia avoids conflicts between authors and even variants of the same mechanism and allows you to select sensible default preferences on many levels: globally, per script, per context or per function call. Asset management ================ Glia allows for multiple assets to refer to the same mechanism by giving them a unique name per package. The standard naming convention is as follows:: glia______ Double underscores in packages, assets or variant names are not allowed. This naming convention allows for multiple people to provide an implementation of the same asset, and by using variants even one package can provide multiple variations on the same mechanism. The default variant is ``0``. If you install multiple packages that provide the same asset, or if you would like to specify another variant you will need to tell Glia which one you require. You can do so by setting your asset preferences. Asset preferences ================= There are 4 different scopes for providing asset preferences (from low to high priority): * **Global scope:** Selects a default mechanism asset everywhere. * **Script scope:** Selects a default mechanism asset for the remainder of the Python script. * **Context scope:** Select a preferred package or variant for all ``glia.insert`` calls within the context block. * **Single use:** Selects a mechanism asset for a single ``glia.insert`` call Single use ~~~~~~~~~~ Whenever you call ``glia.insert`` you can append your preferences for that insert: .. code-block:: python g.insert('Kv1', variant='high_activity', pkg='some_package') # Equivalent to (note the extra parenthesis): g.insert(('Kv1', 'high_activity', 'some_package')) Context scope ~~~~~~~~~~~~~ Any ``glia.insert`` or ``glia.resolve`` call within the with statement will preferably use the given package or variant: .. code-block:: python from patch import p s = p.Section() with g.context(pkg='some_package'): g.insert(s, 'Kv1') g.insert(s, 'Kv1', variant='high_activity') You can also specify a dictionary with multiple asset-specific preferences: .. code-block:: python from patch import p s = p.Section() with g.context(assets={ 'Kv1': {'package': 'some_package', 'variant': 'high_activity'}, 'HCN1': {'variant': 'revised'} }): g.insert(s, 'Kv1') g.insert(s, 'HCN1') # Not affected by the context: g.insert(s, 'Kir2.3') And you can even combine, preferring a certain package unless the dictionary specifies otherwise: .. code-block:: python from patch import p s = p.Section() with g.context(assets={ 'Kv1': {'package': 'specific_preference', 'variant': 'high_activity'}, 'HCN1': {'variant': 'revised'} }, package='base_preference'): g.insert(s, 'Kv1') g.insert(s, 'HCN1') Contexts may be nested, where the innermost context takes precedence. .. warning:: When creating distribution-ready models, set up your models inside of a strict context, with both package and variant explicitly set so that a user's Glia preferences do not affect the reproducibility of your model. .. note:: When using models that set a strict context, the only way to adjust the mechanisms via Glia is to import the package module before Glia, and to set ``package.mods = []``, so that the context fails to find the mechanisms and Glia falls back on your mechanisms. Script scope ~~~~~~~~~~~~ Use ``glia.select`` to select a preferred mechanism asset, similar to the single use syntax, for the remainder of the lifetime of the glia module: .. code-block:: python section_global_Kv1 = h.Section() section_local_Kv1 = h.Section() g.insert(section_global_Kv1, 'Kv1') # Will use your global Kv1 mechanism g.select('Kv1', pkg='not_my_models', variant='high_activity') g.insert(section_local_Kv1, 'Kv1') # Will use the above selected Kv1 mechanism Global scope ~~~~~~~~~~~~ Applying global scope uses the Glia command-line tool and will configure glia to always select a mechanism asset as default. Go to your favorite command-line and enter: .. code-block:: glia select Kv1 --pkg=some_pkg_name --variant=non_default This will set your preference in any script you use.